園芸学部応用生命化学科 / 大学院園芸学研究科


生物化学研究室

Biochemistry Lab.

連携客員教授

宮本 浩邦 

東京医科歯科大学医学部保健衛生学科卒業

慶應義塾大学大学院医学研究科博士課程修了。博士(医学)

好熱菌とその発酵産物が動植物に与える作用機序の解明のために、

千葉大学、並びに理化学研究所などと産学連携研究を進めています。

(兼任:理化学研究所IMS客員主管研究員/本学発VB(株)サーマス/本学連携機関・日環科学(株))

研究業績

2020

Haruka Sagi, Shuichi Shibuya, Tamotsu Kato, Yumiko Nakanishi, Arisa Tsuboi, Shigeharu Moriya, Hiroshi Ohno, Hirokuni Miyamoto, Hiroaki Kodama, Takahiko Shimizu. (2020) SOD1 deficiency alters gastrointestinal microbiota and metabolites in mice. Experimental Gerontology 130(5): 110795.


2018

Shota Yoshikawa, Ryosuke Araoka, Yu Kajihara, Toshiyuki Ito, Hirokuni Miyamoto, Hiroaki Kodama. (2018) Valerate production by Megasphaera elsdenii isolated from pig feces. Journal of Bioscience and Bioengineering 125(5): 519-524.


Yu Kajihara, Shota Yoshikawa, Yuichiro Cho, Toshiyuki Ito, Hirokuni Miyamoto, Hiroaki Kodama. (2017) Preferential isolation of Megasphaera elsdenii from pig feces. Anaerobe 48: 160-164.


宮本浩邦、宮本久、田代幸寛、酒井謙二、児玉浩明 日本生物工学会・生物工学技術賞受賞論文「好熱性微生物を活用した未利用バイオマス資源からの高機能性発酵製品の製造と学術的解明」生物工学会誌、第96巻、第2号 p.56-63 (2018)


2017

Pramod Poudel, Yukihiro Tashiro, Hirokuni Miyamoto, Hisashi Miyamoto, Yuki Okugawa, Kenji Sakai. (2017) Development of a systematic feedback isolation approach for targeted strains from mixed culture systems. Journal of Bioscience and Bioengineering 123: 63-70.


2016

Yukihiro Tashiro, Shota Inokuchi, Pramod Poudel, Yuki Okugawa, Hirokuni Miyamoto, Hisashi Miyamoto, Kenji Sakai. (2016) Novel pH control strategy for efficient production of optically active L-lactic acid from kitchen refuse using a mixed culture system. Bioresource Technology 216: 52-59.


Toshiyuki Ito, Hirokuni Miyamoto*, Yoshifumi Kumagai, Motoaki Udagawa, Toshihito Shinmyo, Kenichi Mori, Kazuo Ogawa, Hisashi Miyamoto and Hiroaki Kodama. (2016) Thermophile-fermented compost extract as a possible feed additive to enhance fecundity in the laying hen and pig: modulation of gut metabolism. Journal of Bioscience and Bioengineering 121: 659-664 (*corresponding author)


Ryusuke Tanaka, Hirokuni Miyamoto*, Shin-ichi Inoue, Kazuhiro Shigeta, Masakazu Kondo, Toshiyuki Itoh, Hiroaki Kodama, Hisashi Miyamoto,Teruo Matsushita. (2016) Thermophile-fermented compost as a fish feed additive modulates lipid peroxidation and free amino acid contents in the muscle in the Carp, Cyprinus carpio. Journal of Bioscience and Bioengineering 121: 530-535 (*corresponding author)


Ayaka Nishida, Hirokuni Miyamoto, Sankichi Horiuchi, Ryo Watanabe, Hidetoshi Morita, Shinji Fukuda, Hiroshi Ohno, Shizuko Ichinose, Hisashi Miyamoto and Hiroaki Kodama. (2015) Bacillus hisashii sp. nov., isolated from the caeca of gnotobiotic mice fed with thermophile-fermented compost. International Journal of Systematic and Evolutionary Microbiology 65: 3944-3949  (co-first author) 


2015

Pramod Poudel, Yukihiro Tashiro, Hirokuni Miyamoto, Hisashi Miyamoto, Yuki Okugawa, Kenji Sakai. (2015) Direct starch fermentation to L-lactic acid by a newly isolated thermophilic stain, Bacillus sp. MC-07. Journal of Industrial Microbiology & Biotechnology, 42: 143-149 


2014

Pramod Poudel, Hirokuni Miyamoto, Hisashi Miyamoto, Yuki Okugawa, Yukihiro Tashiro, Kenji Sakai. (2014) Thermotolerant Bacillus kokeshiiformis sp. nov. isolated from marine animal resources compost. International Journal of Systematic and Evolutionary Microbiology, 64: 2668-2674 


2013

Yukihiro Tashiro, Hiroko Matsumoto, Hirokuni Miyamoto, Yuki Okugawa, Poudel Pramod, Hisashi Miyamoto, Kenji Sakai (2013) A novel production process for optically pure L-lactic acid from kitchen refuse using a bacterial consortium at high temperatures. Bioresource Technology, 146: 672-681  


Hirokuni Miyamoto*, Eiji Shimada, Takashi Satoh, Ryusuke Tanaka, Kenshiro Oshima, Wataru Suda, Shinji Fukuda, Takumi Nishiuchi, Makiko Matsuura, Kenichi Mori, Hisashi Miyamoto, Hiroshi Ohno, Masahira Hattori, Hiroaki Kodama, Teruo Matsushita* (2013) Thermophile-fermented compost as a possible scavenging feed additive to prevent peroxidation. Journal of Bioscience and Bioengineering, ,116(2): 203-208  (*corresponding author)


Hirokuni Miyamoto*, Manami Seta, Sankichi Horiuchi, Yoshikazu Iwasawa, Tomoaki Naito, Ayaka Nishida, Hisashi Miyamoto, Teruo Matsushita, Kikuji Itoh, Hiroaki Kodama (2013) Potential probiotic thermophiles isolated from mice after compost ingestion. Journal of Applied Microbiology,114(4): 1147-1157 (*corresponding author) 


Kazuto Ishikawa, Takashi Ohmori, Hirokuni Miyamoto, Toshiyuki Ito, Yoshifumi Kumagai, Masatoshi Sonoda, Jirou Matsumoto, Hisashi Miyamoto, Hiroaki Kodama. (2013) Denitrification in soil amended with thermophile-fermented compost suppresses nitrate accumulation in plants. Applied Microbiology and Biotechnology, 97(3):1349-1359.  


2012

Takashi Satoh, Takumi Nishiuchi, Tomoaki Naito, Teruo Matsushita, Hiroaki Kodama, Hisashi Miyamoto, Hirokuni Miyamoto*. (2012) Impact of oral administration of compost extract on gene expression in the rat gastrointestinal tract. Journal of Bioscience and Bioengineering, 114(5): 500-505(*corresponding author)  


Hirokuni Miyamoto*, Hiroaki Kodama, Motoaki Udagawa, Kenichi Mori, Jirou Matsumoto, Hatsumi Oosaki, Tatsuo Oosaki, Masayuki Ishizeki, Daisuke Ishizeki, Ryusuke Tanaka, Teruo Matsushita, Yuriko Kurihara, Hisashi Miyamoto. (2012) The oral administration of thermophile-fermented compost extract and its influence on stillbirths and growth rate of pre-weaning piglets. Research in Veterinary Science, 93(1):137-142. (IF:1.330/2011) (*corresponding author)


2011

Kenich Mori, Toshiyuki Ito, Hirokuni Miyamoto*, Mitsuyo Ozawa, Shinji Wada, Yoshifumi Kumagai, Jirou Matsumoto, Rie Naito, Shogo Nakamura, Hiroaki Kodama, Yuriko Kurihara. (2011) Oral administration of multispecies microbial supplements to sows influences the composition of gut microbiota and fecal organic acids in their post-weaned piglets. Journal of Bioscience and Bioengineering, 112(2):145-150.(*corresponding author)


2010

Ryusuke Tanaka, Hirokuni Miyamoto*, Hiroaki Kodama, Nobuhiro Kawachi, Motoaki Udagawa, Hisashi Miyamoto, Teruo Matsushita. (2010) Feed additives with thermophile-fermented compost enhance concentrations of free amino acids in the muscle of the flatfish Paralichthys olivaceus. Journal of General and Applied Microbiology 56(1): 61-65. (*corresponding author)


著書

宮本浩邦、大野博司、児玉浩明 「第7篇 第2章 家畜動物に対するプロバイオティクスとその展望」服部正平監修 ヒトマイクロバイオーム Vo.2 〜解析技術の進展とデータ駆動型・ターゲット機能型研究最前線〜 2020年 出版社: (株) エヌティーエス

http://www.nts-book.co.jp/item/detail/summary/bio/20200600_229.html


宮本浩邦、児玉浩明、大野博司 「畜産・水産分野における抗生物質からの脱却」臨床免疫・アレルギー科 2月号 (第73巻第2号) 132-139  (2020)


宮本浩邦、児玉浩明、大野博司 「家畜・家禽類の生産性を制御する環境微生物-好熱菌・耐熱菌を中心として-」畜産技術 11月号 18-22 (2018)


宮本浩邦、田口仁志 「好熱菌は豚の腸内環境を改善して死亡率を減らす-脱抗菌薬を目指した飼育管理技術の黒豚への適用-」養豚の友 7月号 48-52 (2018)


大野博司、宮本浩邦「腸内細菌叢と宿主の生理・病理」日本動物用医薬品協会会報JVPA Digest6月号 1-20 (2018)


宮本浩邦、児玉浩明「腸内細菌が産生する短鎖脂肪酸で豚の身体をつくる-新規好熱菌を活用した脱抗生物質技術について-」月刊Pig Journal、2018年4月号、p.79-81


宮本浩邦、「22章 環境微生物と動物」、大野博司編「共生微生物」化学同人(Dojin Bioscience series No.27)、p.247-256 (2016)


宮本浩邦、森健一 「脱抗生物質を目指した母豚管理の新技術-腸内フローラの改善による生産性の向上について-」養豚の友 9月号 18-21 (2016)


宮本浩邦、森健一「新しい豚肉ブランド「ノンメタポーク」の事業展開の御紹介脱メタボ社会を意識した生産技術と営業戦略について〜」養豚の友 5月号p.42-45(2015)


宮本浩邦、児玉浩明「動物の脂肪蓄積を制御する好熱菌BP-863とその作用機序」Medical Science Digest、2015年4月号、p.49-51


宮本浩邦、児玉浩明「宿主固有の腸内細菌叢を制御する好熱菌BP-863」月刊細胞、2015年2月号、p.47-48