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園芸学研究科　生物資源科学コース　応用生命化学領域(兼担)

土肥　博史　助教　博士（工学）
物理化学、有機化学

愛知県豊田市生まれ。名古屋大学工学部生物機能工学科を卒業後、同大学院工学研究科物質制御工学専攻を修了し、2002年博士（工学）取得。名古屋大学工学部助手、Ecole Normale Supeieure博士研究員、日本学術振興会特別研究員（DC2, PD）、JST-CREST研究員、千葉大学園芸学部産学官連携研究員、理化学研究所協力研究員などを経て2010年4月より現職。専門は糖鎖工学・有機化学。天然および非天然型生理活性オリゴ糖鎖の合成とその機能化。所属学会は日本農芸化学会、日本糖質学会など。

主な業績

• Miyachi, A., Dohi, H., Neri, P., Mori, H., Uzawa, H., Seto, Y., Nishida, Y.
  “Multivalent Galacto-trehaloses; Design, Synthesis and Biological Evaluation under the Concept of Carbohydrate Modules”
  Biomacromolecules 2009, 10, 1846-1853.
• Chiku, K.; Dohi, H.; Saito, A.; Ebise, H.; Kouzai, Y.; Shinoyama, H.; Nishida, Y.; Ando, A.
  “Enzymatic Synthesis of 4-Hydroxyphenyl β-D-Oligoxylosides and Their Notable Tyrosinase Inhibitory Activity”
  Biosci. Biothechnol. Biochem. 2009, 73, 1123-1128.
• Miyachi, A.; Miyazaki, A.; Shingu, Y.; Matsuda, K.; Dohi, H.; Nishida, Y.
  “Synthesis and Absolute Structures of Mycoplasma Pneumoniae β-Glyceroglycolipid Antigens”
  Carbohydr. Res. 2009, 344, 36-43.
• Neri, P.; Nagano, S-I.; Yokoyama, S.; Dohi, H.; Kobayashi, K.; Miura, T.; Inazu, T.; Sugiyama, T.; Nishida, Y.; Mori, H.
  “Neutralizing activity of polyvalent Gb3, Gb2 and galacto-trehalose models against Shiga toxins”
  Microbiol. Immunol. 2007, 51, 581-592.
• Asada, Y.; Dohi, H.; Kuwahara, S.; Sugai, T.; Kitaura, R.; Shinohara, H.
  “Synthesis and Spectroscopic Characterization of Salmon DNA-wrapped Single-wall Carbon Nanotubes”
  Nano 2007, 2, 295-299.
• Grizot, S.; Salem, M.; Vongsouthi, V.; Durand, L.; Moreau, F.; Dohi, H.; Vincent, S.; Escaich, S.; Ducruix, A.
  “Structure of the Escherichia coli Heptosyltransferase WaaC: Binary Complexes with ADP AND ADP-2-deoxy-2-fluoro Heptose”
  J. Mol. Biol. 2006, 363, 383-394.
• Nishide, D.; Dohi, H.; Wakabayashi, T.; Ishida, M.; Kikuchi, S.; Kitaura, R.; Sugai, T.; Shinohara, H.
  “Single-wall carbon nanotubes encaging linear chain C10H2 polyyne molecules inside”
  Chem. Phys. Lett. 2006, 428, 356-360.
• Dohi, H.; Kikuchi, S.; Kuwahara, S.; Sugai, T.; Shinohara, H.
  “Synthesis and spectroscopic characterization of single-wall carbon nanotubes wrapped by glycoconjugate polymer with bioactive sugars”
  Chem. Phys. Lett. 2006, 428, 98-101.
• Caravano, A; Dohi, H.; Sinay, P.; Vincent, S. P.
  “A new methodology for the synthesis of fluorinated exoglycals and their time-dependent inhibition against UDP-galactopyranose mutase”
  Chem. Eur. J. 2006, 12, 3114-3123.
• Nishida, Y.; Shingu, Y.; Dohi, H.; Kobayashi, K
  “One-pot α-Glycosylation Method Using Appeal Agents in N,N-Dimethylformamide”
  Org. Lett. 2003, 5, 2377-2380.
• Shingu, Y.; Nishida, Y.; Dohi, H.; Kobayashi, K.
  “An Easy Access to Halide Ion-catalitic α-Glycosylation Using Carbon Tetrabromide and Triphenylphosphine as Multifunctional Reagents”
  Org. Biomol. Chem. 2003, 1, 2518-2512.
• Nishida, Y.; Tsurumi, T.; Sasaki, K.; Watanabe, K.; Dohi, H.; Kobayashi, K.
  “Design and Synthesis of C3-Symmetric LewisX Antigen”
  Org. Lett. 2003, 5, 3775-3778.
• Dohi, H.; Nishida, Y.; Furuta, Y.; Uzawa, H.; Yokoyama, S-I.; Ito, S.; Mori, H.; Kobayashi, K.
  “Molecular Design and Biological Potential of Galacto-Type Trehalose as a Nonnatural Ligand of Shiga Toxins”
  Org. Lett. 2002, 4, 355-357.
• Uzawa, T.; Kamiya, S.; Minoura, N.; Dohi, H.; Nishida, Y.; Taguchi, K.; Yokoyama, S-I.; Mori, H.; Shimizu, T.; Kobayashi, K.
  “A Quarts Microbalance (QCM) Method for Rapid Detection and Differentiation of Shiga Toxins, Stx-1 and Stx-2, Applying a Monoalkyl Globobioside as the Toxin Ligand”
  Biomacromolecules 2002, 3, 411-414.
• Miura, Y.; Sasao, Y.; Dohi, H.; Nishida, Y.; Kobayashi, K.
  “Self-assembled monolayers of globotriaosylceramide (Gb3) mimics: suface-specific affinity with Shiga toxins”
  Anal. Biochem. 2002, 310, 27-35.
• Shingu, Y.; Nishida, Y.; Dohi, H.; Kobayashi, K.
  “Convenient Access to Halide Ion-catalized α-Glycosylation Free from Noxious Fumes at the Donor Synthesis”
  J. Carbohydr. Chem. 2002, 21, 605-611.
• Dohi, H.; Nishida, Y.; Tanaka, H.; Kobayashi, K.
  “o-Methoxycarbonylphenyl 1-thio-β-D-Galactopyranoside, A Non-malodorous Thio Glycosylation Donor for the Synthesis of Globosyl α (1-4)-Linkages”
  Synlett. 2001, 1446-1448.
• Dohi, H.; Nishida, Y.; Mizuno, M.; Shinkai, M.; Kobayashi, T.; Takeda, T.; Uzawa, H.; Kobayashi, K.
  “Synthesis of an Artificial Glycoconjugate Polymer Carrying Pk-Antigenic Trisaccharide and its Potent Neutralization Activity against Shiga-like toxin”
  Bioorg. Med. Chem. 1999, 7, 2053-2062.
• Nishida, Y.; Dohi, H.; Uzawa, H.; Kobayashi, K.
  “Synthesis of Artificial Glycoconjugate Polymers Carrying Biologically Active Trisaccharides with α-D-Galactopyranosyl (1-3) and (1-4)-Linkage”
  Tetrahedron Lett. 1998, 39, 8681-8684.