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園芸学研究科　生物資源科学コース　応用生命化学領域

平井　静　助教　博士(農学)
担当授業：食品衛生学、栄養化学等

京都府京都市生まれ。京都大学農学部卒業、同大学院農学研究科応用生物科学専攻・修士、博士課程修了（動物栄養科学）。その後、同研究科食品生物科学専攻・産学官連携研究員を経て、2009年7月より現職。専門は、分子栄養学、食品機能学。肥満および生活習慣病の予防に有効な食品成分の探索およびその機構解明を行っている。所属学会は、日本栄養・食糧学会、日本肥満学会等。

主な業績

原著論文

• Shizuka Hirai, Taku Uemura, Teruo Kawada, et al. Diosgenin attenuates inflammatory changes in the interaction between adipocytes and macrophages. Molecular Nutrition & Food Research. 2009. in press.
• Min-Sook Kang, Shizuka Hirai, Teruo Kawada, et al. Dehydroabietic acid, a diterpene, improves diabetes and hyperlipidemia in obese diabetic KK-Ay mice. Dehydroabietic acid, a diterpene, improves diabetes and hyperlipidemia in obese diabetic KK-Ay mice. Biofactors. 2009. in press.
• Teruo Kawada, Tsuyoshi Goto, Shizuka Hirai, et al. Dietary regulation of nuclear receptors in obesity-related metabolic syndrome. Asia Pacific Journal of Clininal Nutrition. 17, Suppl 1, 126-130. 2008.
• Min-Sook Kang, Shizuka Hirai, Teruo Kawada et al. Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation. Biochemistry and Biophysiology Research Communications. 369, 333-338. 2008.
• Kayo Kuroyanagi, Min-Sook Kang, Tsuyoshi Goto, Shizuka Hirai, et al. Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes. Biochemistry and Biophysiology Research Communications. 366, 219-225. 2008.
• Nobuyuki Takahashi, Min-Sook Kang, Kayo Kuroyanagi, Tsuyoshi Goto, Shizuka Hirai, et al. Auraptene, a citrus fruit compound, regulates gene expression as a PPARα agonist in HepG2 hepatocytes. Biofactors. 33, 25-32. 2008.
• Shizuka Hirai, Yong-il Kim, Teruo Kawada, et al. Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages. Life Sciences. 81, 1272-1279. 2007.
• Shizuka Hirai, Haruka Matsumoto, Hideo Yano, et al. Follistatin rescues the inhibitory effect of activin A on the differentiation of bovine preadipocyte. Domestic Animal Endocrinology. 33, 269-280. 2007.
• Shizuka Hirai, Haruka Matsumoto, Hideo Yano, et al. Myostatin inhibits differentiation of bovine preadipocyte. Domestic Animal Endocrinology. 32, 1-14. 2007.
• Shizuka Hirai, Mai Yamanaka, Hideo Yano, et al. Activin A Inhibits differentiation of 3T3-L1 preadipocyte. Molecular and Cellular Endocrinology. 232, 21-26. 2005.
• Taeil Jeon, Seong Gu Hwang, Shizuka Hirai, Dong Ki Park. Red yeast rice extracts suppress adipogenesis by down-regulating adipogenic transcription factors and gene expression in 3T3-L1 cells. Life Sciences. 75, 3195-3203. 2004.
• Shizuka Hirai, Hiroyuki Kawachi, Tohru Matsui, Hideo Yano. Effects of Protein Deficiency on the mRNA Expression of Insulin-Like Growth Factors in Liver and Muscle of Weaned Lambs. Animal Science Journal. 75, 207-212. 2004.

著書

• Nobuyuki Takahashi, Tsuyoshi Goto, Shizuka Hirai, Teruo Kawada, et al. Genome science of lipid metabolism and obesity. in : Food Factors for Health Promotion (T.Yoshikawa,Eds). KARGER, 2009. in press.
• Teruo Kawada, Tsuyoshi Goto, Shizuka Hirai, et al. Obesity and Nuclear Receptors: Effective Genomic Strategies in Functional Foods. in : NUTRIGENOMICS AND PROTEOMICS IN HEALTH AND DISEASE (Yoshinori Mine, Kazuo Miyashita and Fereidoon Shahidi,Eds), p.47-58. WILEY-BLACK WELL, 2009.
• Tsuyoshi Goto, Nobuyuki Takahashi, Shizuka Hirai, Teruo Kawada. Isoprenols : Effective Genomic Strategies in Functional Foods. in : NUTRIGENOMICS AND PROTEOMICS IN HEALTH AND DISEASE (Yoshinori Mine, Kazuo Miyashita and Fereidoon Shahidi,Eds), p.301-310. WILEY-BLACK WELL, 2009.
• 平井静、後藤剛、柳 梨娜、高橋信之、河田照雄　肥満・メタボリックシンドロームと食品機能、｢肥満と脂肪エネルギー代謝－メタボリックシンドロームへの戦略－｣　建帛社、2008.
• 平井静、楠堂達也、向井佐輝子、河田照雄　培養脂肪細胞の分化プロトコール、「糖尿病カレントライブラリー7　脂肪細胞と脂肪組織」文光堂、2007.

総説

• 河田照雄、後藤剛、平井静、高橋信之 脂質代謝と生活習慣病・メタボリックシンドローム 「生物工学」86, 469-487. 2008.
• 平井静、柳 梨娜、河田照雄　肥満と食品機能成分－脂肪細胞の特性とその形成制御機構、「Functional Food」Vol. 1 No. 2. 2008.
• 平井静、河田照雄　PPARγと脂肪細胞分化、「別冊・医学のあゆみ　PPARと疾患」、53-57. 2008.
• 河内浩行、平井静 脂肪細胞分化のオートクリン・パラクリン因子：アクチビン、「The Lipid」 17(4), 63-67. 2006.
• 平井静、河内浩行、矢野秀雄、河田照雄　脂肪細胞分化の分子メカニズム～C/EBPβ,δの新たな機能、「細胞」38(6), 219-223. 2006.
• 河内浩行、平井静 筋細胞からのパラクリン因子による脂肪細胞分化制御に関する研究、｢栄養生理研究会報｣ 50(1), 17-33. 2006.
• 矢野秀雄、平井静、北川政幸　肉用牛研究の最新の進歩、｢栄養生理研究会報｣ 48 (2), 79-104. 2004.