学部・大学院
Academics

土肥　博史

土肥　博史　准教授　博士（工学）
物理化学、有機化学

土肥　博史土肥　博史

氏名

土肥　博史
職位

准教授
学位

博士（工学）
所属
  • 園芸学研究科　生物資源科学コース　応用生命化学領域　生命分子化学分野
  • 園芸学部　応用生命化学科　応用生命化学プログラム　生命分子化学分野
居室 西千葉キャンパス　自然科学系総合研究棟2号館9階
電話 043-290-3944
E-mail hdohi@
faculty.chiba-u.jp

愛知県豊田市生まれ。名古屋大学工学部生物機能工学科を卒業後、同大学院工学研究科物質制御工学専攻を修了し、2002年博士（工学）取得。名古屋大学工学部助手、Ecole Normale Supeieure博士研究員、日本学術振興会特別研究員（DC2, PD）、JST-CREST研究員、千葉大学園芸学部産学官連携研究員、理化学研究所協力研究員などを経て2010年4月より現職。専門は糖鎖工学・有機化学。天然および非天然型生理活性オリゴ糖鎖の合成とその機能化。所属学会は日本農芸化学会、日本糖質学会など。

主な業績

  1. Miyachi, A., Dohi, H., Neri, P., Mori, H., Uzawa, H., Seto, Y., Nishida, Y."Multivalent Galacto-trehaloses; Design, Synthesis and Biological Evaluation under the Concept of Carbohydrate Modules"Biomacromolecules 2009, 10, 1846-1853.
  2. Chiku, K.; Dohi, H.; Saito, A.; Ebise, H.; Kouzai, Y.; Shinoyama, H.; Nishida, Y.; Ando, A."Enzymatic Synthesis of 4-Hydroxyphenyl β-D-Oligoxylosides and Their Notable Tyrosinase Inhibitory Activity"Biosci. Biothechnol. Biochem. 2009, 73, 1123-1128.
  3. Miyachi, A.; Miyazaki, A.; Shingu, Y.; Matsuda, K.; Dohi, H.; Nishida, Y."Synthesis and Absolute Structures of Mycoplasma Pneumoniae β-Glyceroglycolipid Antigens"Carbohydr. Res. 2009, 344, 36-43.
  4. Neri, P.; Nagano, S-I.; Yokoyama, S.; Dohi, H.; Kobayashi, K.; Miura, T.; Inazu, T.; Sugiyama, T.; Nishida, Y.; Mori, H."Neutralizing activity of polyvalent Gb3, Gb2 and galacto-trehalose models against Shiga toxins"Microbiol. Immunol. 2007, 51, 581-592.
  5. Asada, Y.; Dohi, H.; Kuwahara, S.; Sugai, T.; Kitaura, R.; Shinohara, H."Synthesis and Spectroscopic Characterization of Salmon DNA-wrapped Single-wall Carbon Nanotubes"Nano 2007, 2, 295-299.
  6. Grizot, S.; Salem, M.; Vongsouthi, V.; Durand, L.; Moreau, F.; Dohi, H.; Vincent, S.; Escaich, S.; Ducruix, A."Structure of the Escherichia coli Heptosyltransferase WaaC: Binary Complexes with ADP AND ADP-2-deoxy-2-fluoro Heptose"J. Mol. Biol. 2006, 363, 383-394.
  7. Nishide, D.; Dohi, H.; Wakabayashi, T.; Ishida, M.; Kikuchi, S.; Kitaura, R.; Sugai, T.; Shinohara, H."Single-wall carbon nanotubes encaging linear chain C10H2 polyyne molecules inside"Chem. Phys. Lett. 2006, 428, 356-360.
  8. Dohi, H.; Kikuchi, S.; Kuwahara, S.; Sugai, T.; Shinohara, H."Synthesis and spectroscopic characterization of single-wall carbon nanotubes wrapped by glycoconjugate polymer with bioactive sugars"Chem. Phys. Lett. 2006, 428, 98-101.
  9. Caravano, A; Dohi, H.; Sinay, P.; Vincent, S. P."A new methodology for the synthesis of fluorinated exoglycals and their time-dependent inhibition against UDP-galactopyranose mutase"Chem. Eur. J. 2006, 12, 3114-3123.
  10. Nishida, Y.; Shingu, Y.; Dohi, H.; Kobayashi, K"One-pot α-Glycosylation Method Using Appeal Agents in N,N-Dimethylformamide"Org. Lett. 2003, 5, 2377-2380.
  11. Shingu, Y.; Nishida, Y.; Dohi, H.; Kobayashi, K."An Easy Access to Halide Ion-catalitic α-Glycosylation Using Carbon Tetrabromide and Triphenylphosphine as Multifunctional Reagents"Org. Biomol. Chem. 2003, 1, 2518-2512.
  12. Nishida, Y.; Tsurumi, T.; Sasaki, K.; Watanabe, K.; Dohi, H.; Kobayashi, K."Design and Synthesis of C3-Symmetric LewisX Antigen"Org. Lett. 2003, 5, 3775-3778.
  13. Dohi, H.; Nishida, Y.; Furuta, Y.; Uzawa, H.; Yokoyama, S-I.; Ito, S.; Mori, H.; Kobayashi, K."Molecular Design and Biological Potential of Galacto-Type Trehalose as a Nonnatural Ligand of Shiga Toxins"Org. Lett. 2002, 4, 355-357.
  14. Uzawa, T.; Kamiya, S.; Minoura, N.; Dohi, H.; Nishida, Y.; Taguchi, K.; Yokoyama, S-I.; Mori, H.; Shimizu, T.; Kobayashi, K."A Quarts Microbalance (QCM) Method for Rapid Detection and Differentiation of Shiga Toxins, Stx-1 and Stx-2, Applying a Monoalkyl Globobioside as the Toxin Ligand"Biomacromolecules 2002, 3, 411-414.
  15. Miura, Y.; Sasao, Y.; Dohi, H.; Nishida, Y.; Kobayashi, K."Self-assembled monolayers of globotriaosylceramide (Gb3) mimics: suface-specific affinity with Shiga toxins"Anal. Biochem. 2002, 310, 27-35.
  16. Shingu, Y.; Nishida, Y.; Dohi, H.; Kobayashi, K."Convenient Access to Halide Ion-catalized α-Glycosylation Free from Noxious Fumes at the Donor Synthesis"J. Carbohydr. Chem. 2002, 21, 605-611.
  17. Dohi, H.; Nishida, Y.; Tanaka, H.; Kobayashi, K."o-Methoxycarbonylphenyl 1-thio-β-D-Galactopyranoside, A Non-malodorous Thio Glycosylation Donor for the Synthesis of Globosyl α (1-4)-Linkages"Synlett. 2001, 1446-1448.
  18. Dohi, H.; Nishida, Y.; Mizuno, M.; Shinkai, M.; Kobayashi, T.; Takeda, T.; Uzawa, H.; Kobayashi, K."Synthesis of an Artificial Glycoconjugate Polymer Carrying Pk-Antigenic Trisaccharide and its Potent Neutralization Activity against Shiga-like toxin"Bioorg. Med. Chem. 1999, 7, 2053-2062.
  19. Nishida, Y.; Dohi, H.; Uzawa, H.; Kobayashi, K."Synthesis of Artificial Glycoconjugate Polymers Carrying Biologically Active Trisaccharides with α-D-Galactopyranosyl (1-3) and (1-4)-Linkage"Tetrahedron Lett. 1998, 39, 8681-8684.
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